National Guard presence at border to be reduced (AP)

WASHINGTON ? When the number of National Guard troops stationed at the Mexican border is reduced next year, their duties are expected to shift from being on the border to flying above it.

About 1,200 troops now help Border Patrol agents spot illegal border crossers and human and drug smugglers. The office of Rep. Michael McCaul, R-Texas, said Tuesday that number will be reduced. It is unclear how many troops will remain.

A federal official briefed on the new strategy said the reduced force will focus their efforts on aerial surveillance. The official spoke on the condition of anonymity because the plan has not been announced.

Lt. Col. Robert L. Ditchey, a Defense Department spokesman, said officials are still working out details of the future of Guard troops at the border.

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20111214/ap_on_re_us/us_border_security_troops

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Animal welfare groups: don't buy pet store puppies (AP)

LOS ANGELES ? More puppies are sold at pet stores during the holiday season than any other time of year. Now the American Society for the Prevention of Cruelty to Animals and other groups are stepping up efforts to stop these sales, saying many of these dogs come from puppy mills.

Forty billboards in Los Angeles this month encourage people to fight puppy mills by boycotting pet stores and websites that sell puppies. More than 50,000 people have signed a pledge on the ASPCA's website vowing to uphold the boycott, and the ASPCA has an online database of targeted stores at nopetstorepuppies.com encouraging consumers to shop elsewhere. Consumers can also report a store to the ASPCA, and the organization will verify the source of its puppies, Menkin said.

"We are not just saying `Don't buy a puppy,' but `Don't buy anything in a pet store that sells puppies," said Cori Menkin, senior director of the ASPCA's anti-puppy mills campaign. "If pet stores are not able to turn a profit, they will stop selling puppies."

The Humane Society of the United States, Best Friends Animal Society and many other groups are promoting similar initiatives.

As malls and chains drop the commercial sale of puppies, one change for consumers is an increase in convenient locations for shelter adoptions.

In October, Jack's Pets announced they would no longer sell puppies at their 27 stores in Ohio, Kentucky and Indiana. They are working with shelters to offer in-store adoptions instead. Major chains like PetSmart Inc. and Petco Animal Supplies Inc. stopped selling dogs and cats several years ago, partnering with local shelters and rescues on weekend adoption events. Best Friends has helped several traditional pet stores convert to shelter sales.

Macerich Co., a regional shopping mall company, recently announced a ban on traditional pet stores at its 70 malls. Instead, at the company's mall in Lakewood, Calif., shoppers will find a store called Adopt & Shop, which gets its animals from the Southeast Area Animal Control Authority shelter. On Nov. 25, the store celebrated its 500th adoption, said Aimee Gilbreath, executive director of Found Animals, the organization that runs and subsidizes Adopt & Shop.

Some pet store owners say they're being unfairly maligned.

Jens Larsen, who owns Perfect Pets in Littleton, Colo., is on the ASPCA list and says it's not right. He has been in business for 18 years, sold 1,600 puppies last year and has an A-plus rating with the Better Business Bureau. He gets 80 percent of his dogs from commercial breeders in Nebraska, 10 percent from breeders in Kansas and Oklahoma and 10 percent from two Colorado breeders, he said.

Some animal activists are "radical and fanatical and want to put me out of business," he said. "I obey the law. So do my breeders and the kennels I deal with," Larsen said.

Larsen says that when you are selling 100 puppies a month, there will occasionally be a case of kennel cough or a parasite, and every once in a while, something more serious. But he believes if his dogs were continually getting sick, word would spread and he'd be out of business.

About 2 million puppies are sold online and in U.S. pet stores every year, said Menkin.

The ASPCA and other animal welfare groups have popularized a negative image of commercial dog breeders in recent years, claiming that poor breeding practices and substandard conditions leave some animals with chronic physical ailments, genetic defects or fear of humans.

Whether it's the impact of bad publicity or the recession cutting into purebred dog sales, the number of commercial dog breeders licensed by the U.S. Department of Agriculture is declining, from 3,486 in 2009, to 2,904 in 2010 and 2,205 in 2011, according to USDA spokesman Dave Sacks said.

Licenses in Missouri, with three times more breeders than any other state, dropped from 1,221 in 2009 to 745 this year, Sacks said. Iowa, Oklahoma, Kansas, Arkansas, Ohio and Indiana have between 100 and 300 licensed breeders. Sixteen states have none. Sacks says the USDA protects animals by making unannounced inspections of breeding facilities and by regulating food, care and housing for the animals.

Serena Brant believes her golden retriever, Ali, was a puppy mill dog. When Brant bought the 4-month-old pup 10 years ago from Perfect Pets for $400, Ali's papers had numbers instead of names listed for parents. Her first trip to the vet cost $800 to treat giardia, fleas and eye infections, said Brant, of Littleton, Colo.

Two years later, the dog started limping. X-rays showed hip dysplasia. Surgery, at $12,000 for both hips, was an option but came without guarantees, so Brant chose to medicate the dog instead. Then Ali got arthritis.

For the last six years, Ali has to stop every 50 feet to rest. Because of the medication, "we don't think she's in pain," said Brant. But over the years, the medicine has totalled $8,600.

"I am not going to put a dog down just because she's defective. We have the money to provide for her so we will," she said.

But next time she gets a dog, Brant says, she'll adopt one from a shelter.

Source: http://us.rd.yahoo.com/dailynews/rss/pets/*http%3A//news.yahoo.com/s/ap/20111213/ap_on_re_us/us_fea_pets_pet_store_puppies

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BLABBERMOUTH.NET - CANCER BATS: 'Dead Set On Living ...

Canadian metallers CANCER BATS will release their fourth album, "Dead Set On Living", in April 2012 via via Distort Inc.

A video teaser for the CD containing a sample of the track "R.A.T.S." ? featuring a guest appearance by guitarist/vocalist Rob Urbinati of Canadian thrash metal veterans SACRIFICE ? can be seen below.

In a recent interview with Blare magazine, CANCER BATS vocalist Liam Cormier stated about the forthcoming album, "I think sound-wise there's definitely more of the natural evolution of how gnarly we keep getting and how more refined everyone sounds. I'd say the majority of our fans now have seen our band live and know how gnarly and ferocious it is, so trying to compress that into a recording still is kind of difficult. Like we'd say, I thought we did it pretty well on 'Bears',' and then we'd re-examine that and we'd see there's still some elements that are missing." Bassist Jaye Schwarzer added, "But there's always stuff that comes up with every record, like what haven't we really captured yet. With doing the [BLACK] SABBATH covers at Sonisphere [festival] and then going into writing this one and thinking about how they had written their songs, we tried to apply some of that into what we're doing. Different elements are always going to come up when recording a new record. We'd always ask ourselves, 'What haven't we done?' and 'How can I make this better?' and doing that made it way more interesting." Cormier continued, "I think the big thing too is the realization that we're always going to be CANCER BATS. And from looking at BLACK SABBATH, we realized that even though BLACK SABBATH are these four guys, none of them are doing the same thing at the exact same time. Like none of it lines up at any point but it all works so well, to the point where you don't even notice it. That was a big thing. We used to feel that all the parts playing along together would sound tighter, but now we've found that everyone confidently playing their own part makes the whole thing sound tighter and more cohesive. On this album, nothing sits on top of anything because it's all got its own distinct voice."

CANCER BATS was nominated in the "Rock Album of the Year" category at the 2011 Juno Awards (the Canadian equivalent of the Grammy Awards). The band faced off against fellow Canadians DIE MANNEQUIN, FINGER ELEVEN, HAIL THE VILLIAN and MATTHEW GOOD.

CANCER BATS's third studio album, "Bears, Mayors, Scraps & Bones", sold around 600 copies in the United States in its first week of release. The CD landed at position No. 95 on the Top New Artist Albums (Heatseekers) chart, which lists the best-selling albums by new and developing artists, defined as those who have never appeared in the Top 100 of The Billboard 200.

"Bears, Mayors, Scraps & Bones" was made available on April 13, 2010 via Good Fight Music. CANCER BATS also released a digital EP containing "Scared to Death" and its take on the BEASTIE BOYS classic "Sabotage". The EP is available on iTunes.

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Source: http://www.roadrunnerrecords.com/blabbermouth.net/news.aspx?mode=Article&newsitemID=167237

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McCain: Billions in US aid to Pakistan in jeopardy (AP)

WASHINGTON ? Sen. John McCain says the billions of U.S. aid to Pakistan must come with strings attached.

The top Republican on the Senate Armed Services Committee, which helps to oversee that money, says Pakistan should show it's helping to "prevent the needless deaths of young Americans."

McCain's comment on CNN's "State of the Union" shows the acute frustration in Congress because of alleged ties between Pakistan's intelligence outfit and anti-U.S. insurgents.

U.S.-Pakistan relations have become even more strained after NATO airstrikes killed 24 Pakistani troops along the Afghanistan border. Pakistan retaliated by shutting down U.S. supply lines.

The Arizona lawmaker says the U.S. should "explore all alternatives," although he did not provide specifics.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20111204/ap_on_go_co/us_us_pakistan

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'Label-free' imaging tool tracks nanotubes in cells, blood for biomedical research

ScienceDaily (Dec. 5, 2011) ? Researchers have demonstrated a new imaging tool for tracking structures called carbon nanotubes in living cells and the bloodstream, which could aid efforts to perfect their use in biomedical research and clinical medicine.

The structures have potential applications in drug delivery to treat diseases and imaging for cancer research. Two types of nanotubes are created in the manufacturing process, metallic and semiconducting. Until now, however, there has been no technique to see both types in living cells and the bloodstream, said Ji-Xin Cheng, an associate professor of biomedical engineering and chemistry at Purdue University.

The imaging technique, called transient absorption, uses a pulsing near-infrared laser to deposit energy into the nanotubes, which then are probed by a second near-infrared laser.

The researchers have overcome key obstacles in using the imaging technology, detecting and monitoring the nanotubes in live cells and laboratory mice, Cheng said.

"Because we can do this at high speed, we can see what's happening in real time as the nanotubes are circulating in the bloodstream," he said.

Findings are detailed in a research paper posted online Dec. 4 in the journal Nature Nanotechnology.

The imaging technique is "label free," meaning it does not require that the nanotubes be marked with dyes, making it potentially practical for research and medicine, Cheng said.

"It's a fundamental tool for research that will provide information for the scientific community to learn how to perfect the use of nanotubes for biomedical and clinical applications," he said.

The conventional imaging method uses luminescence, which is limited because it detects the semiconducting nanotubes but not the metallic ones.

The nanotubes have a diameter of about 1 nanometer, or roughly the length of 10 hydrogen atoms strung together, making them far too small to be seen with a conventional light microscope. One challenge in using the transient absorption imaging system for living cells was to eliminate the interference caused by the background glow of red blood cells, which is brighter than the nanotubes.

The researchers solved this problem by separating the signals from red blood cells and nanotubes in two separate "channels." Light from the red blood cells is slightly delayed compared to light emitted by the nanotubes. The two types of signals are "phase separated" by restricting them to different channels based on this delay.

Researchers used the technique to see nanotubes circulating in the blood vessels of mice earlobes.

"This is important for drug delivery because you want to know how long nanotubes remain in blood vessels after they are injected," Cheng said. "So you need to visualize them in real time circulating in the bloodstream."

The structures, called single-wall carbon nanotubes, are formed by rolling up a one-atom-thick layer of graphite called graphene. The nanotubes are inherently hydrophobic, so some of the nanotubes used in the study were coated with DNA to make them water-soluble, which is required for them to be transported in the bloodstream and into cells.

The researchers also have taken images of nanotubes in the liver and other organs to study their distribution in mice, and they are using the imaging technique to study other nanomaterials such as graphene.

The paper was written by doctoral student Ling Tong; postdoctoral research associate Yuxiang Liu; doctoral students Bridget D. Dolash and Yookyung Jung; biomedical engineering research scientist Mikhail N. Slipchenko; Donald E. Bergstrom, the Walther Professor of Medicinal Chemistry; and Cheng.

The research is funded by the National Science Foundation.

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The above story is reprinted from materials provided by Purdue University. The original article was written by Emil Venere.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Ling Tong, Yuxiang Liu, Bridget D. Dolash, Yookyung Jung, Mikhail N. Slipchenko, Donald E. Bergstrom, Ji-Xin Cheng. Label-free imaging of semiconducting and metallic carbon nanotubes in cells and mice using transient absorption microscopy. Nature Nanotechnology, 2011; DOI: 10.1038/nnano.2011.210

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/12/111205170213.htm

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Brooke Mueller Arrested For Cocaine Possession, Assault (omg!)

Brooke Mueller, ex-wife of Charlie Sheen and mother to the pair's 2-year-old twin sons, was arrested on Friday night in Aspen, Colo., on suspicion of felony cocaine possession and assault, Access Hollywood has confirmed.

According to a statement provided to Access by a rep for the Aspen Police Department, at approximately 11:32 PM, officers were "on a routine walk through" when they made contact with a woman who reported an assault had taken place.

PLAY IT NOW: Access Hollywood Live: Kathy Hilton On Brooke Mueller?s Addiction Struggles

"The woman identified Brooke Mueller, 34, of Los Angeles, California as the aggressor," the statement read. "After midnight, December 3, 2011, Aspen Police located Mueller at [the nightclub] Escobar, 426 E. Hyman Ave, Aspen.

"Mueller was arrested and charged with assault in the third degree (class one misdemeanor) and possession of cocaine with intent to distribute (class four felony)," the statement continued. "Mueller posted bond of $11,000 and was released with a District Court date of December 19, 2011."

VIEW THE PHOTOS: A Look Back at Charlie Sheen & Brooke Mueller

Mueller has been in and out of rehab multiple times in the past.

Her arrest comes just shy of two years after then-husband Charlie Sheen was arrested on Christmas Day 2009, following a domestic dispute with Mueller at the Aspen home they shared.

Sheen was eventually sentenced to rehab and probation for the incident as well as 36 hours of domestic violence treatment counseling.

VIEW THE PHOTOS: Celebs Who Have Been In Rehab

Copyright 2011 by NBC Universal, Inc. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://us.rd.yahoo.com/dailynews/rss/entertainment/*http%3A//us.rd.yahoo.com/dailynews/external/omg_rss/rss_omg_en/news_brooke_mueller_arrested_cocaine_possession_assault184947265/43793794/*http%3A//omg.yahoo.com/news/brooke-mueller-arrested-cocaine-possession-assault-184947265.html

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Holiday shopping for your favorite foodie

A round-up of food-related ideas for your 2011 holiday gift list.

The time has come again. Thanksgiving is all over but the leftovers, and it is time to turn to holiday shopping. I love putting together this round up of some of my holiday fun finds, and as always, these are just some ideas about personal favorites ? no one has asked me to promote any products.

Skip to next paragraph Perre Coleman Magness

Perre Magness has studied food and cooking around the world, mostly by eating, but also through serious study. Coursework at Le Cordon Bleu London and intensive courses in Morocco, Thailand and France has broadened her own culinary skill and palate. The kitchen of choice is at home, cooking like most people, experimenting with unique but practical ideas.

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This year, I am all about homemade gifts from the kitchen. I went on a real canning bender this summer, so I have a kitchen full of jars of lovely goodies to give away. I think homemade gifts are a real gesture of caring, and everyone appreciates something good to eat. And I know I like my packaging to be worthy of the treats inside. If treats in jars is your plan, dress them up with some lovely personalized canning labels. These letterpress labels add a sleek, modern feel to good old-fashioned preserves and pickles. Tie on a little personalized ribbon and you are good to go.?

But if baking is your way of showing love, doll up those treat with pretty bags?and boxes of all types. These Baked with Love hang tags add an old-fashioned charm, while letterpress write-in tags work for all your kitchen gifts. And there are some amazing labels for bags and boxes of baked goods, from simple?to festive. I think adding a custom recipe card to a homemade gift is a wonderfully sweet addition.

If you are looking for gifts for your food loving friends, Jacques Pepin?s Essential Pepin?may be the cookbook of the season. It comes with a searchable DVD of Jacques demonstrating his techniques. New Orleans chef John Besh?s My Family Table?will be a great companion in the kitchen for family meals. And as winter settles in, Diana Henry?s Roast Figs and Sugar Snow will make you want to cook warming, comforting food.? But settling down with a juicy read after the holidays is a great gift too.? White Truffles in Winter is a fictionalized love story about the first celebrity chef Auguste Escoffier. And while reading a delectable novel, a cup of Novel Tea, tea for book lovers, wouldn?t go amiss.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/DpQa8zlNda8/Holiday-shopping-for-your-favorite-foodie

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Encourage Children to Earn Money for Digital Items Through Entrepreneurial Actions [Parent Hacks]

These days kids not only want video games and traditional toys but also online tokens, "soul gems", and other digital currency items for the games they play online. If you're a parent and allow your child to play these types of games you have to decide where they will fund the extras the game will require?do you just pay it yourself or do you make the child use their allowance?

Personal finance weblog Man Vs. Debt author Adam Baker's young daughter wanted to buy extra virtual tokens for a kiddie-MMO, Baker responded by asking what she think she could do to earn a little extra spending money. Turns out the kid loves to make paintings and her dad and her worked out a plan to sell several of her paintings to relatives at six quarters each. The girl painted five or six paintings, an activity she enjoys, and sold all of her paintings to relatives who were eager to add her work to their refrigerator.

Whether it's a lemonade stand, cookies, or even finger paintings, encouraging the entrepreneurial spirit in your children will teach them about the work that goes into earning money and they may even decide not to spend their hard-won quarters on frivolous downloads. Baker's daughter has yet to spend the quarters she earned painting.

Raising Entrepreneurial Kids | Man Vs. Debt

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/956vm63mKs0/encourage-children-to-earn-money-for-digital-items-through-entrepreneurial-actions

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Tumor-targeting compound points the way to new personalized cancer treatments

ScienceDaily (Dec. 1, 2011) ? One major obstacle in the fight against cancer is that anticancer drugs often affect normal cells in addition to tumor cells, resulting in significant side effects. Yet research into development of less harmful treatments geared toward the targeting of specific cancer-causing mechanisms is hampered by lack of knowledge of the molecular pathways that drive cancers in individual patients.

"A major goal of cancer research is to replace chemotherapy with drugs that correct specific molecular pathways disrupted by cancer," says Dr. Ari Melnick, one of the study's lead investigators and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences and associate professor of medicine at Weill Cornell Medical College. "But looking for mutations isn't always the way to find the most important factors that are keeping cancer cells alive."

Through a collaboration among Weill Cornell Medical College, the Sloan-Kettering Institute at Memorial Sloan-Kettering Cancer Center and the National Cancer Institute (NCI), a team of scientists has now reported that a tumor-targeting compound called PU-H71 can reveal with great accuracy the set of altered pathways that contribute to malignancy. Because the drug specifically binds to abnormal protein complexes in cancer cells, it could lead to the development of more targeted and effective therapies that produce fewer side effects. These findings were recently published in the journal Nature Chemical Biology.

"The holy grail in the field was to develop some way to figure out what factors keep cancer cells alive, regardless of whether they have mutations," says Dr. Melnick. "In this paper, we present a method to do just that."

Through nearly a decade of research, PU-H71 was discovered and refined in the laboratory of Dr. Gabriela Chiosis, associate member of the Molecular Pharmacology and Chemistry Program at the Sloan-Kettering Institute and an associate attending chemist of Memorial Hospital, Memorial-Sloan Kettering Cancer Center. Dr. Chiosis, who is the senior investigator in this new study, reported initial findings about the drug five years ago. The compound was designed to inhibit heat shock protein 90 (Hsp90), which helps other proteins fold into the correct three-dimensional shape and function properly.

Hsp90 plays an essential role in the ability of cells to tolerate stress. The altered growth and metabolism of tumors induce a high degree of stress in these cells. To cope with this stress, tumor cells produce a special form of Hsp90 that is tuned to specially protect those proteins required for their growth and survival. Because this tumor/stress form of Hsp90 regulates many pathways that go awry in cancer, it is a more promising drug target than current targets that play a role in only a single pathway, Dr. Chiosis says. Importantly, PU-H71 specifically suppresses the cancer form of Hsp90 but has little effect on Hsp90 in normal cells.

Several years ago, Dr. Chiosis partnered with Dr. Melnick to examine the effectiveness of PU-H71 in treating breast cancer and lymphomas, and they have previously reported that the drug has dramatic antitumor effects without being toxic to animals. As a result of the drug's success in fighting these two aggressive types of cancer, the research team received approval from the National Cancer Institute to carry out clinical trials. Patients are currently being recruited for the first trial, which will test the drug's safety in treating a variety of tumor types, and subsequent clinical trials are being planned for patients with lymphomas, breast cancer, chemotherapy-resistant leukemia and other specific types of cancer.

In their new study Dr. Chiosis, Dr. Melnick, and collaborators demonstrated that because PU-H71 binds to tumor-Hsp90, and tumor-Hsp90 binds to proteins that are required for tumor survival, it is possible to use PU-H71 as a method to "fish out" entire networks of abnormal proteins in tumor cells in an unbiased fashion, which has not been possible up until now. Importantly, many or even most of the genes encoding proteins that maintain tumor cell survival are not mutated in tumors. Hence genetic screening would not be able to detect these networks, Dr. Melnick says. "The value of this method is that it's the first time you can go and probe the functional proteome, or the whole set of proteins that are important to maintaining the tumor." This strategy opens up new avenues for understanding in greater detail the molecular basis of cancer and identifying novel drug targets.

For example, in chronic myeloid leukemia cells, the PU-H71 drug preferentially binds to the Hsp90 complex containing Bcr-Abl, an abnormal protein that is overactive in these cells, rather than to Hsp90 associated with the normal protein Abl. Similar findings were observed in other tumor types, with PU-H71-Hsp90 complexes protecting only the tumor-associated proteins.

The researchers then used PU-H71 and proteomic analyses to identify all of the abnormal proteins bound to Hsp90 in chronic myeloid leukemia cells and built networks of these proteins using bioinformatics analyses. They found that these proteins are part of signaling pathways involved in cell death, growth and division. Bcr-Abl is known to use many of these pathways to propagate abnormal signaling in this type of cancer cell. The researchers experimentally confirmed that proteins from these pathways are crucial for cancer cell growth, division and survival, suggesting that their approach can be used to accurately identify Bcr-Abl-related protein networks. Moreover, the same experiments identified many proteins not previously known to drive chronic myeloid leukemia cells. One example of such a protein was CARM1, a regulator of gene expression, which the investigators showed maintains survival of these tumor cells.

Importantly, this PU-H71 cancer proteome method can also be used to identify networks of abnormal proteins in the cells from individual patients, paving the way to personalized therapies that target multiple pathways. "No two tumors are exactly alike, and we don't really know what is driving cancer in one patient versus the other," the researchers say. "If you can use this method to identify in a given individual the factors that are maintaining that patient's particular cancer, then you could develop targeted drugs that hit these specific factors -- in effect, designing personalized therapy for individual patients."

Based on these findings, Dr. Melnick and Dr. Chiosis recently received a multi-investigator collaborative grant from the National Cancer Institute to use this new PU-H71 proteome method to identify the proteins that maintain the survival of lymphoma cells. This funding is an example of how collaboration between investigators and institutions can synergistically accelerate the pace of biomedical research.

Study collaborators include Kamalika Moulick, James Ahn, Anna Rodina, Erica Gomes DaGama, Eloisi Caldas-Lopes, Fabiana Perna, Ly Vu, Xinyang Zhao, Danuta Zatorska, Tony Taldone, Mary Alpaugh, Stephen Nimer, Peter Smith-Jones, Nagavarakishore Pillarsetty, Thomas Ku, Jason Lewis, Steven Larson, Ross Levine and Hediye Erdjument-Bromage of Memorial Sloan-Kettering Cancer Center in New York City; Hongliang Zong, Leandro Cerchietti, Katerina Hatzi, Steven Gross and Monica Guzman of Weill Cornell Medical College; and Kristin Beebe and Len Neckers of the National Cancer Institute in Bethesda, Md.

This work was supported in part by the National Cancer Institute, Leukemia and Lymphoma Society, the Breast Cancer Research Fund, the SPORE Pilot Award and Research and Therapeutics Program in Prostate Cancer, the Hirshberg Foundation for Pancreatic Cancer Research, the Byrne Fund and the V Foundation for Cancer Research.

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Journal Reference:

1. Kamalika Moulick, James H Ahn, Hongliang Zong, Anna Rodina, Leandro Cerchietti, Erica M Gomes DaGama, Eloisi Caldas-Lopes, Kristin Beebe, Fabiana Perna, Katerina Hatzi, Ly P Vu, Xinyang Zhao, Danuta Zatorska, Tony Taldone, Peter Smith-Jones, Mary Alpaugh, Steven S Gross, Nagavarakishore Pillarsetty, Thomas Ku, Jason S Lewis, Steven M Larson, Ross Levine, Hediye Erdjument-Bromage, Monica L Guzman, Stephen D Nimer, Ari Melnick, Len Neckers, Gabriela Chiosis. Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature Chemical Biology, 2011; 7 (11): 818 DOI: 10.1038/nchembio.670

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/12/111201163558.htm

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Spain asks extradition in Salvador priest killings (AP)

MADRID, Spain ? Spain is asking the United States and El Salvador to extradite 15 former Salvadoran military officials in the killings of six Jesuit priests and two civilians in 1989.

The former officials formed El Salvador's military leadership when the killings occurred during a military attack on a university in San Salvador. The Central American country was involved then in a civil war that killed some 75,000 people.

Spain wants the extradition of two people from the U.S. and 13 from El Salvador on charges of murder, terrorism and crimes against humanity. Five of the six slain priests were Spaniards.

El Salvador's Supreme Court has twice this year refused the extradition of former military officials indicted by a Spanish judge in the killings.

Source: http://us.rd.yahoo.com/dailynews/rss/latam/*http%3A//news.yahoo.com/s/ap/20111202/ap_on_re_eu/eu_spain_el_salvador_priest_killings

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How you can Move with your Household pets Around -- fjmuseum.com

When moving to a different place of residence you?ll certainly not want your pets being left behind. After all, they have been a part of the loved ones for a long and have spent time as well as emotions together. In moving areas, pets also should be regarded secondly right after all of your personal belongings. Phoenix moving company tells that moving can be a stressful matter for persons and it truly is the same together with your pets. But somewhat know how of this matter, the trip might be pleasant for each you as well as your pet.

Many moving company in Phoenix will allow pets inside their vehicles. Before travelling, it truly is superior to give pets water in the morning as well as restrict the amount of food you will let them have the night ahead of the travel. If travelling demands nighttime journey, restrict also the food you will give them at night. Kennels of huge canines should be placed on the vehicle first, then place each and every canine one by one after the kennel is in its proper place. Usually do not forget to bring along water as well as food for pets so they will not get starved until you reach house. Leashes of pets should be placed around the kennel door so it?ll be prepared as soon as essential. To get a mess free travel, generally keep a poop scooper prepared. As travel maybe too significantly stressful for pets, make sure to give them items to maintain them comfortable as well as calm like blanket or favored toys. Domestic pets should also be kept secure in their kennels or cages by making confident that the doors are closed securely and effectively. Domestic pets could move across the vehicle and get into furniture and boxes that could outcome to injuries.

Through stopovers or when at rest region, it truly is superior to walk canines and cats to relieve them from anxiety. If time permits which you quit inside a hotel, give your pets little food. Let canines out of their kennels along with the cats outdoors of their cage. If the hotel has a pet area, you?ll be able to leave them there until finally you have enough rest and are set to continue your vacation.

Source: http://www.fjmuseum.com/how-you-can-move-with-your-household-pets-around.html

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No. 10 USC blasts UCLA 50-0 in season finale

UCLA quarterback Kevin Prince, right, is sacked by Southern California cornerback Nickell Robey during the first half of an NCAA college football game in Los Angeles, Saturday, Nov. 26, 2011. (AP Photo/Jae Hong)

UCLA quarterback Kevin Prince, right, is sacked by Southern California cornerback Nickell Robey during the first half of an NCAA college football game in Los Angeles, Saturday, Nov. 26, 2011. (AP Photo/Jae Hong)

Southern California quarterback Matt Barkley celebrates a touchdown by teammate Rhett Ellison during the first half of an NCAA college football game against UCLA in Los Angeles on Saturday, Nov. 26, 2011. (AP Photo/Jae Hong)

Southern California quarterback Matt Barkley looks to throw during the first half of an NCAA college football game against UCLA, Saturday, Nov. 26, 2011, in Los Angeles. (AP Photo/Jae Hong)

Southern California wide receiver Marqise Lee, right, is congratulated on his touchdown by teammate Randall Telfer during the first half of an NCAA college football game against UCLA in Los Angeles on Saturday, Nov. 26, 2011. (AP Photo/Jae Hong)

UCLA wide receiver Josh Smith(7) is tackled by Southern California safety Tony Burnett(34) during the second half of an NCAA college football game in Los Angeles, Saturday, Nov. 26, 2011. (AP Photo/Jae Hong)

LOS ANGELES (AP) ? UCLA showed up at the Coliseum in unfamiliar all-white uniforms, flouting tradition and radiating confidence for their annual showdown with Southern California.

A few hours later, the Bruins probably wished they had packed more disguises.

Matt Barkley passed for 423 yards and six touchdowns in his possible Coliseum farewell, Robert Woods set the conference's single-season receptions record while catching 12 passes for 113 yards and two TDs, and No. 10 USC finished its resurgent season with a 50-0 demolition of Pac-12 title game-bound UCLA on Saturday night.

Kevin Prince passed for 261 yards for the Bruins (6-6, 5-4 Pac-12), who had won three of four heading into the city championship game. The Bruins changed up their look for a game usually played in both clubs' colored home uniforms, but the Trojans left them with nothing but grass stains on the backs of those slick new jerseys, posting the third-biggest blowout in rivalry history and shutting out UCLA for just the second time in 64 years.

USC won seven of its final eight games capped by this utter obliteration of the Bruins, who will represent the division at Oregon next week despite finishing two games behind the Trojans in the South standings.

"Life still goes on. We still have the opportunity to do something big in the Pac-12 championship," said UCLA tailback Derrick Coleman, who was stopped on fourth-and-goal at the USC 1 in the first quarter. "That was a shot to the gut for everybody. We can't take anything for granted. We've got to go out and take it."

After the game, the Trojans wore T-shirts proclaiming themselves to be the South division champions. UCLA had no room to argue after the postseason-banned Trojans still went out in style, jumping to a 29-point halftime lead before posting their largest victory in the city championship game since 1930, the rivalry's second year.

"Tonight they were clearly the superior team," UCLA coach Rick Neuheisel said. "I don't think that's the case all the time. I believe we can close the gap, and we will. We weren't good enough to play a marquee team like USC."

Earlier this week, Neuheisel said he felt the Bruins had "closed the gap more" with the Trojans, who won 10 games for the eighth time in the past decade.

Mind the gap, UCLA.

"They took it very personally," USC coach Lane Kiffin said of his players. "That's a pretty strong statement to make. Did it motivate them? I don't know, but it was talked about a lot, and not much by me. I think they felt disrespected."

Despite the Bruins' Pac-12 title game berth, Neuheisel's job is thought to be in jeopardy after his fourth inconsistent season. Athletic director Dan Guerrero said Neuheisel will coach in Friday's title game, but the program will be evaluated after that.

Marqise Lee had 13 catches for 224 yards and two TDs during a showcase of offensive brilliance by the Trojans (10-2, 7-2).

"We've worked hard for this, and I think we deserve to celebrate this," said Barkley, who surpassed Matt Leinart's single-season conference record for touchdown passes. "We knew (about the postseason ban) coming into this year, and there's nothing we can do about it. We just tried to take advantage of every opportunity we did have."

With the Coliseum crowd repeatedly chanting "One more year!" Barkley was brilliant in what might have been the junior's final game at USC. He went 35 for 42 and set a Pac-12 record with his 39th touchdown pass early in the fourth quarter, hitting Woods from 41 yards out to surpass Leinart's mark. Barkley also surpassed his own school record set earlier this year with 35 completions.

Barkley and left tackle Matt Kalil are near-certain first-round NFL draft picks, but they claim they haven't decided whether to return for their senior seasons and a shot at a national title with a team that's likely to be among the nation's most talented next year despite severe NCAA scholarship restrictions that start in 2012. Barkley again declined to speculate on his decision, saying he'll figure it out soon.

"Unless he wants to do it, just to be a special Trojan, he ain't coming back," Kiffin said. "He's every bit ready to go to the NFL. It's just going to be a decision, does he want to do something really unique? He might be the guy to do that."

Woods broke Keyshawn Johnson's 1995 record with his 103rd catch during the first half, while Lee joined Woods as a 1,000-yard receiver. Rhett Ellison and Randall Telfer also caught TD passes from Barkley, who had 29 scoring passes and just four interceptions in his last eight games.

Curtis McNeal added a 73-yard TD run as USC beat UCLA for the 12th time in the last 13 meetings.

Kiffin had no mercy on his rival while claiming the Victory Bell. USC went for a 2-point conversion after its third touchdown, and Barkley attempted 50-yard passes in his first two plays after halftime, hitting Lee for a 52-yard score with the second throw to take a 36-0 lead. Kiffin and Neuheisel still shared a warm postgame handshake.

The Bruins failed to score on three drives inside the USC 25 in the first half, with Prince throwing an end-zone interception to T.J. McDonald. USC's defense preserved its first shutout since Nov. 1, 2008, by stopping the Bruins on fourth down at the 7 with 2:48 to play.

USC hadn't shut out UCLA since 2001, the only other time since 1947.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2011-11-27-FBC-T25-UCLA/id-d58d6bea6e634152a3f8a7b85718d75f

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